agoodwinsmith: (Default)
agoodwinsmith ([personal profile] agoodwinsmith) wrote2024-02-02 11:54 am
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Alzheimers and Human Growth Hormone

I have just read something that makes me want to run around and hyperventilate. It makes me feel that over-reacting may indeed be the proper reaction. However, (a) knees, and (2) I don't know enough to be more than freaked out in ignorance.

So this popular article says that Alzheimers can be transmitted from person to person:
https://www.msn.com/en-ca/health/other/alzheimer-s-transmitted-from-person-to-person/ar-BB1hrh6d
Alzheimer's transmitted from person to person

It turns out that in the early days of treating children with Human Growth Hormone, the hormone was derived from deceased donors, and was indeed called "cadaver-derived human growth hormone or c-hGH". Synthetic hormone has been used since the 1980s. Apparently, people treated as children with the c-hGH later went on to develop Alzheimers, and enough of them showed that they were unlikely to have developed the disease in the normal course of events that a paper was published about it.

Here is the published paper:
https://www.nature.com/articles/s41591-023-02729-2
Iatrogenic Alzheimer’s disease in recipients of cadaveric pituitary-derived growth hormone

IMPORTANT
At no time does either article suggest that Alzheimers (or its precursors) can be transmitted from person to person in the regular course of being alive and living together. However, medical procedures (types of therapy and instruments) *can* be agents of transmission. These risks are super rare - but not zero. Corneal surgery is mentioned. (Cataract surgery, anyone?)

Okay. So the hyperventilation wasn't in relation to increased risk of developing Alzheimers, but that this may point to potential avenues of therapeutic intervention. The freaked out was because it probably won't since we are obsessed with single tau-trouncing pill remedies that will fit a pharmaceutical corporation fee structure.